Mitchell O’Connell

Dr. Mitchell O’Connell

Assistant Professor of Biochemistry and Biophysics at University of Rochester
Mitchell O'Connell
Dr. Mitchell O’Connell is an Assistant Professor of Biochemistry and Biophysics at University of Rochester and a member of the Center for RNA Biology. After obtaining his PhD in Biochemistry at the University of Sydney, Mitchell was a postdoctoral fellow in the lab of Dr. Jennifer Doudna at the University of California, Berkeley, where he made a number of discoveries related to the ability for CRISPR systems to target RNA. Most notably, Mitchell discovered that the well-known gene editing tool CRISPR-Cas9 is also able to target RNA and can be harnessed as tool to study RNA biology in humans and other organisms. In 2017, he moved to Rochester and set his own lab, which focuses on understanding the biochemical mechanisms of RNA-mediated gene regulation, and on the development of new CRISPR-based tools to study these processes. The lab is particularly interested in how RNA processing is involved in the control and dynamics of fundamental biological processes (such as cell fate decision and maintenance, and neuronal function) and how these processes are dysregulated in disease.

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